We are interested in understanding how adaptive immune cells traffic into the brain and mediate pathological glial activation that inhibits myelin repair and causes progressive axonal degeneration in multiple sclerosis.
The lab utilizes a combination of animal models, advanced imaging techniques, and in vitro work with human iPSCs to interrogate mechanisms of injury and develop strategies for neuroprotection and repair.
On this website:
The Calabresi Lab is supported by:
National Institutes of Health:
R01NS041435: “Mechanisms by which effector T cells modulate endogenous remyelination”
R01NS082347: “Imaging Neurodegeneration in Multiple Sclerosis”
U01NS111678: “Neurofilament light (NfL) chain as a biomarker in multiple sclerosis”
Department of Defense:
W81XWH1910622: “Targeting Neurotoxic Glia to Promote Myelin Repair and Neuroprotection”
National Multiple Sclerosis Society:
NMSS 1907-34756: “Mechanisms of complement component 3 mediated neurodegeneration in MS and EAE”
NMSS 1904-33800: “Validation of Serum Neurofilament Light Chain as Biomarker in Multiple Sclerosis Subtypes and Controls”